Oncotarget

Clinical Research Papers:

Lymph node status in different molecular subtype of breast cancer: triple negative tumours are more likely lymph node negative

Ning Liu, Zhigang Yang, Xiaozhen Liu and Yun Niu _

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Oncotarget. 2017; 8:55534-55543. https://doi.org/10.18632/oncotarget.15022

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Abstract

Ning Liu1, Zhigang Yang2, Xiaozhen Liu3 and Yun Niu3

1 Department of Pathology, Bao Di Hospital, Bao Di Clinical College of Tianjin Medical University, Tianjin, China

2 Tianjin Baodi Hospital of Traditional Chinese Medicine, Tianjin, China

3 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China

Correspondence to:

Ning Liu, email:

Keywords: breast cancer, molecular subtype, triple negative subtype, lymph node status, prognosis

Received: October 25, 2016 Accepted: January 09, 2017 Published: February 02, 2017

Abstract

Background and Objectives: To investigate the association between different molecular subtype (MST) and the axillary lymph nodal (ALN) status.

Materials and Methods: A total of 528 female patients with primary breast cancer were collected. Survival estimates were calculated using the Kaplan-Meier method, univariate and multivariate logistic regression models.

Results: Triple negative and Luminal A breast cancers were more frequently node-negative (N0) when compared to Luminal B and Her-2 positive cancers (77.4% and 73.4% vs. 45.3% and 40.0%, respectively; P < 0.0001). We observed a clearly significant difference among ALN status in patients with Her-2 positive (P = 0.001) and Luminal B (P < 0.0001) breast cancer. While no significant prognostic diffreence among different LN status was detected in the Triple negative (P = 0.070) and Luminal A subtype (P = 0.660). On the other hand, we detected no prognostic diffreence among different MST in N1 and N3 subgroups (P = 0.569 and P = 0.484, respectively). Multivariate analysis showed that lymph node status (P < 0.01), molecular subtype (P < 0.01), and tumor size (P < 0.01) were significantly and independently prognostic factors. The c-index of the prognosis nomogram for recurrence prediction was 0.70.

Conclusion: Triple negative breast cancer is not associated more frequently with a higher number of involved nodes. The prognosis nomogram can predict the probability of recurrence patients within 3 or 5 years.


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