Serum and tissue leptin in lung cancer: A meta-analysis
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Xiang Tong1, Yao Ma1, Qilong Zhou2, Jie He3, Bo Peng4, Sitong Liu1, Zhipeng Yan1, Xin Yang1, Hong Fan1
1Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China
2Innovative Drug Research Centre, Chongqing University, Chongqing, 404100, China
3Department of Respiratory Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China
4Department of Internal Medicine, Hospital of Tradition Medicine LS.SC, Leshan, 614000, China
Keywords: lung cancer, cachexia, leptin, risk, meta-analysis
Received: April 15, 2016 Accepted: January 03, 2017 Published: February 01, 2017
Many studies have found that leptin is involved in tumorigenesis and the progression of lung cancer. However, these studies were inconsistent. Therefore, we performed a meta-analysis to investigate the role of leptin in the patients with lung cancer. A systematic literature search in the several databases and on commercial Internet search engines was carried out to identify studies published up to July 8, 2016. The standardized mean difference (SMD) and odds ratio (OR) with 95% confidence interval (CI) were used to investigate the effect sizes. Finally, 21 eligible articles were included in the current meta-analysis. Overall, there is no relationship between levels of serum leptin and lung cancer. However, a subgroup analysis in high-study quality group found a weak association between serum leptin concentrations and lung cancer in Chinese (SMD=0.77, P=0.035). Additionally, the meta-analysis indicates that the serum leptin levels were lower in the weight-losing group than in the sustained weight group (SMD=-0.80, P=0.001). Further, there was evidence of a significant association between expression levels of leptin protein in tissue and lung cancer (OR=7.35, P<0.001). The present meta-analysis suggests that the serum and tissue leptin may be involved in the pathogenesis of lung cancer and tumor metastasis, especially among Chinese. However, the leptin may not appear to play an important role in cancer cachexia development.
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