Oncotarget

Research Papers:

Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer

Tiantian Lu, Suying Dang, Rui Zhu, Ying Wang, Zongying Nie, Tao Hong and Wei Zhang _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:18979-18990. https://doi.org/10.18632/oncotarget.14866

Metrics: PDF 2688 views  |   HTML 2807 views  |   ?  


Abstract

Tiantian Lu1,*, Suying Dang2,3,*, Rui Zhu1, Ying Wang1, Zongying Nie1, Tao Hong1, Wei Zhang1

1Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Science, East China Normal University, Shanghai, China

2Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3Shanghai Research Center for Model Organisms, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Suying Dang, email: [email protected]

Wei Zhang, email: [email protected]

Keywords: ADAMTS18, colitis-associated colorectal cancer, inflammation, tumorigenesis

Received: September 14, 2016     Accepted: January 18, 2017     Published: January 27, 2017

ABSTRACT

ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. In AOM/DSS–induced colitis-associated colorectal cancer, the deficiency of Adamts18 in mice resulted in enhanced tumorigenesis and colon inflammation that could be attributed in part to enhanced nuclear translocation of β-catenin and elevated expression of its downstream target genes, cyclin D1 and c-myc. Moreover, increased p38MAPK and ERK1/2 activities were detected in colon cancer cells from Adamts18-deficient mice. Further studies revealed that ADAMTS18 deficiency reduced intestinal E-cadherin levels in mice, which ultimately led to intestinal barrier dysfunction. These data indicate that Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/β-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in this mouse model.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 14866