Fertility-sparing uterine lesion resection for young women with gestational trophoblastic neoplasias: single institution experience

Xiaoyu Wang; Junjun Yang; Jie Li; Jun Zhao; Tong Ren; Fengzhi Feng; Xirun Wan; Yang Xiang

doi:10.18632/oncotarget.14727

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Clinical Research Papers:

Fertility-sparing uterine lesion resection for young women with gestational trophoblastic neoplasias: single institution experience

Xiaoyu Wang, Junjun Yang, Jie Li, Jun Zhao, Tong Ren, Fengzhi Feng, Xirun Wan and Yang Xiang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:43368-43375. https://doi.org/10.18632/oncotarget.14727

Metrics: PDF 1361 views | HTML 1808 views | ?

Abstract

Xiaoyu Wang1, Junjun Yang1, Jie Li1, Jun Zhao1, Tong Ren1, Fengzhi Feng1, Xirun Wan1 and Yang Xiang1

1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China

Correspondence to:

Yang Xiang, email:

Keywords: gestational trophoblastic neoplasias; fertility-sparing surgery; uterine lesion resection; prognostic factor; pregnant outcomes

Received: November 02, 2016 Accepted: January 09, 2017 Published: January 18, 2017

Abstract

Purpose: To evaluate the oncological safety and pregnant outcomes of fertility-sparing uterine lesion resection in treating gestational trophoblastic neoplasias.

Results: After the treatment of surgery and chemotherapy, all the patients achieved complete remission. With a median follow-up time of 44 months (range, 6-188), 3 patients (3.85%) relapsed within 3-26 months. Multivariate analysis showed that tumor size was the independent risk factor of recurrence and the cutoff value was 4.2cm. Among 37 patients who attempted to conceive, 31 achieved clinical pregnancy. The rate of pregnancy and live birth were 83.8% and 77.4%. Uterine rupture did not occurred no matter in cesarean section or vaginal delivery. No congenital abnormalities were reported among the live births.

Methods: From January 1995 to December 2014, 78 patients with gestational trophoblastic neoplasias who underwent fertility-sparing uterine lesion resection at Peking Union Medical College Hospital were reviewed. The complete remission rate, fertility rate, pregnant outcomes and risk factors of recurrence were analyzed.

Conclusions: Fertility-sparing uterine lesion resection might be considered as a safe and reasonable alternative for high-selected young women to remove uterine lesion in the treatment of gestational trophoblastic neoplasias.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14727

Publication Alerts

Clinical Research Papers:

Fertility-sparing uterine lesion resection for young women with gestational trophoblastic neoplasias: single institution experience

Abstract