Oncotarget

Methodological Research Paper:

Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo

Yichuan Pang, An Qin, Xianfeng Lin, Lin Yang, Qiang Wang, Zhengke Wang, Zhi Shan, Shengyun Li, Jiying Wang, Shunwu Fan and Qiaoling Hu _

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Oncotarget. 2017; 8:35583-35591. https://doi.org/10.18632/oncotarget.14709

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Abstract

Yichuan Pang1,*, An Qin2,*, Xianfeng Lin3, Lin Yang1, Qiang Wang3, Zhengke Wang1, Zhi Shan3, Shengyun Li3, Jiying Wang3, Shunwu Fan3 and Qiaoling Hu1

1 Department of Polymer Science and Engineering, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China

2 Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3 Department of Orthopaedics, Sir Shaw Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, China

* These authors have contributed equal to this work

Correspondence to:

Qiaoling Hu, email:

An Qin, email:

Shunwu Fan, email:

Keywords: chitosan, elastic scaffold, osteogenesis, tissue engineering

Received: April 24, 2016 Accepted: December 05, 2016 Published: January 17, 2017

Abstract

Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold. Therefore, this new chitosan material might lead to the manufacture of a variety of novel biodegradable biomedical materials and devices.


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