Oncotarget

Research Papers:

Low rate of positive margins and re-excision after partial mastectomy in highly selected breast cancer patients: A Chinese single-institution experience

Siyu Wu, Yanyan Zhu, Zhaozhi Yang, Miao Mo, Hongbo Gao, Wentao Yang _ and Guangyu Liu

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Oncotarget. 2017; 8:12225-12233. https://doi.org/10.18632/oncotarget.14686

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Abstract

Siyu Wu1,*, Yanyan Zhu2,*, Zhaozhi Yang3,*, Miao Mo4, Hongbo Gao5, Wentao Yang6, Guangyu Liu1

1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China

2Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai, P.R. China

3Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China

4Clinical Statistics Center, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China

5Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China

6Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Wentao Yang, email: [email protected]

Guangyu Liu, email: [email protected]

Keywords: low rate, positive margins, highly selected, partial mastectomy, Chinese

Received: June 29, 2016     Accepted: December 27, 2016     Published: January 17, 2017

ABSTRACT

A recent randomized controlled trial firstly demonstrated that cavity shaving significantly decreased the rate of positive margins and re-excision among partial mastectomy (PM) patients. However, it remains unknown whether cavity shaving should be routinely applied to Chinese breast cancer patients undergoing PM. A total of 408 PM patients undergoing 410 PMs among 1796 surgically treated breast cancer patients at Fudan University Shanghai Cancer Centre from January 2015 to June 2015 were included in our study. Data were analysed with univariate or multivariate analysis. Overall, 11 of 410 cases (2.7%) had positive margins postoperatively. Moreover, only 24.6% of the cases (P<0.05) presented with ductal carcinoma in situ (DCIS), among whom 10.0% obtained positive margins. In multivariate logistic regression analysis, presence of mammographic calcifications was significantly associated with margin positivity (P<0.05, OR=6.06, 95% CI: 1.53-23.91). In conclusion, cavity shaving during PM should not be routinely performed in Chinese breast cancer patients, particularly in highly selected cases with a low prevalence of DCIS. PM patients with preoperative mammographic calcifications were more likely to have positive margins and might benefit more from cavity shaving.


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