Significant association between Let-7-KRAS rs712 G > T polymorphism and cancer risk in the Chinese population: a meta-analysis
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Xin-Ya Du1,*, Yuan-Yuan Hu2,*, Chun Xie1,*, Chun-Yan Deng3, Cai-Yun Liu2, Zhi-Guo Luo5, Yu-Ming Niu2,4, Ming Shen6,7
1Department of Stomatology, People’s Hospital of New District Longhua Shenzhen, Shenzhen 518109, China
2Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
3Intensive Care Unit, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
4Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
5Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
6Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, China
7Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China
*These authors contributed equally to this work
Yu-Ming Niu, email: [email protected]
Ming Shen, email: [email protected]
Keywords: let-7, KRAS, polymorphism, cancer
Received: August 23, 2016 Accepted: January 06, 2017 Published: January 16, 2017
Association between let-7-KRAS rs712 polymorphism and cancer risk was inconsistent. We therefore conducted this meta-analysis to clarify the association between let-7-KRAS rs712 polymorphism and cancer risk with STATA 14.0 software. A systemic literature search in online databases (PubMed, Embase, CNKI and Wanfang database) was preformed to obtain relevant articles. A total of 13 case-control studies involving 3,453 patients and 4,470 controls were identified up to May 16, 2015. The pooled results indicated that significantly increased risk were observed in Chinese population in T vs. G (OR = 1.21, 95% CI = 1.03–1.42) and TT vs. GG + GT genetic models (OR = 1.69, 95% CI = 1.17–2.42). Sensitivity analysis was conducted and the result without heterogeneity showed significant associations in all five genetic models. Subgroup analyses of cancer type indicated a similar result in digestive cancer (for T vs. G: OR = 1.41, 95% CI = 1.26–1.57; GT vs. GG: OR = 1.24, 95% CI = 1.07–1.43; TT vs. GG: OR = 2.53, 95% CI = 1.86–3.44; GT + TT vs. GG: OR = 1.36, 95% CI = 1.19–1.56; TT vs. GG + GT: OR = 2.35, 95% CI = 1.73–3.19). In summary, these evidences demonstrate that let-7-KRAS rs712 G > T polymorphism might be associated with digestive system cancer risk in the Chinese population.
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