Research Papers:
BI-RADS 3–5 microcalcifications can preoperatively predict breast cancer HER2 and Luminal a molecular subtype
Metrics: PDF 1996 views | HTML 3990 views | ?
Abstract
DongZhi Cen1,*, Li Xu2,*, Ningna Li2,*, Zhiguang Chen2,*, Lu Wang2,*, Shuqin Zhou2,*, Biao Xu2,*, Chun ling Liu3, Zaiyi Liu3, Tingting Luo4
1Department of Radiation Oncology and Department of Nuclear Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong Province, People’s Republic of China
2Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou, Guangdong Province 510120, P.R. China
3Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province 510080, People's Republic of China
4Department of Ultrasound, The Third People’s Hospital of Shenzhen, Guangdong Shenzhen 518112, China
*These authors contributed equally to this work
Correspondence to:
Zaiyi Liu, email: [email protected]
Keywords: calcification, infiltrating ductal carcinoma, mammography, logistic regression, breast cancer molecular subtype
Received: September 20, 2016 Accepted: January 07, 2017 Published: January 14, 2017
ABSTRACT
Purpose: To investigate associations between breast cancer molecular subtype and the patterns of mammographically detected calcifications.
Results: Identified were 93 (19.1%) Luminal A, 242 (49.9%) Luminal B, 108 (22.2%) HER2 and 42 (8.7%) basal subtypes. In univariate analysis, the clinicopathological parameters and BI-RADS 3–5 microcalcifications, which consisted 9 selected features was significantly associated with breast cancer molecular subtype (all P < 0.05). Among subtypes, multivariate analysis showed that calcification >2 cm in range (OR: 1.878, 95% CI: 1.150 to 3.067) and calcification > 0.5 mm in diameter (OR:2.206, 95% CI: 1.235 to 3.323) was independently predictive of HER2 subtype. The model showed good discrimination for predicting HER2 subtype, with a C-index of 0.704. In addition, multivariate analysis showed that calcification morphology (amorphour or coarse heterogenous calcifications OR: 2.847, 95% CI: 1.526 to 5.312) was independently predictive of Luminal A subtype. The model showed good discrimination for predicting Luminal A subtype, with a C-index of 0.74. And we demonstrated that amorphour or coarse heterogenous calcifications were associated with a higher incidence of Luminal A subtype than pleomorphic or fine linear or branching calcifications. There was no significant difference between breast cancer subtypes (Luminal B vs. other; Basal vs. other) and the patterns of mammographically detected calcifications.
Materials and Methods: Mammographic images of 485 female patients were included. The correlation between mammographic imaging features and breast cancer subtype was analyzed using Chi-square test, univariate and binary logistic regression analysis.
Conclusions: This study shows that BI-RADS 3–5 microcalcifications can be conveniently used to facilitate the preoperative prediction of HER2 and Luminal A molecular subtype in patients with infiltrating ductal carcinoma.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14655