Research Papers:

Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females

Yu-Xiao Sun _, Chuan-Yu Gao, Yang Lu, Xin Fu, Jun-Ge Jia, Yu-Jie Zhao, Lian-Dong Li, Hong-zhi Dui, Xing-Yu Zhang, Zhi-Ying Li, Lei Lei, Wei-Feng Zhang and Yi-Qiang Yuan

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Oncotarget. 2017; 8:13166-13173. https://doi.org/10.18632/oncotarget.14486

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Yu-Xiao Sun1, Chuan-Yu Gao2, Yang Lu3, Xin Fu4, Jun-Ge Jia1, Yu-Jie Zhao1, Lian-Dong Li1, Hong-zhi Dui1, Xing-Yu Zhang1, Zhi-Ying Li1, Lei Lei1, Wei-Feng Zhang1, Yi-Qiang Yuan1

1Department of Cardiology, The Seventh People’s Hospital, Zhengzhou, Henan, 450016, China

2Department of Cardiology, Henan Provincial People’s Hospital, Zhengzhou, 450000, China

3Department of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

4Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Correspondence to:

Yu-Xiao Sun, email: [email protected]

Yi-Qiang Yuan, email: [email protected]

Keywords: coronary heart disease (CHD), single nucleotide polymorphisms (SNPs), PPAP2B, Chinese Han population, case-control study

Received: October 29, 2016    Accepted: December 15, 2016    Published: January 04, 2017


Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066–1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the “GC” haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population.

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PII: 14486