Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma
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Linda Boldrup1, Xiaolian Gu1, Philip J. Coates2, Lena Norberg-Spaak3, Robin Fahraeus1,2,4, Göran Laurell3,5, Torben Wilms3, Karin Nylander1
1Department of Medical Biosciences/Pathology, Umeå University, SE – 901 85 Umeå, Sweden
2RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic
3Department of Clinical Sciences/ENT Umeå University, SE – 901 85 Umeå, Sweden
4Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France
5Department of Surgical Sciences/ENT, Uppsala University,752 36 Uppsala, Sweden
Linda Boldrup, email: [email protected]
Keywords: tongue cancer, RNA expression, field cancerization
Received: August 24, 2016 Accepted: December 05, 2016 Published: December 27, 2016
Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.
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