Research Papers:

Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma

Linda Boldrup _, Xiaolian Gu, Philip J. Coates, Lena Norberg-Spaak, Robin Fahraeus, Göran Laurell, Torben Wilms and Karin Nylander

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Oncotarget. 2017; 8:19389-19402. https://doi.org/10.18632/oncotarget.14288

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Linda Boldrup1, Xiaolian Gu1, Philip J. Coates2, Lena Norberg-Spaak3, Robin Fahraeus1,2,4, Göran Laurell3,5, Torben Wilms3, Karin Nylander1

1Department of Medical Biosciences/Pathology, Umeå University, SE – 901 85 Umeå, Sweden

2RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic

3Department of Clinical Sciences/ENT Umeå University, SE – 901 85 Umeå, Sweden

4Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France

5Department of Surgical Sciences/ENT, Uppsala University,752 36 Uppsala, Sweden

Correspondence to:

Linda Boldrup, email: [email protected]

Keywords: tongue cancer, RNA expression, field cancerization

Received: August 24, 2016    Accepted: December 05, 2016    Published: December 27, 2016


Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.

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