Research Perspectives:

VEGF-independent angiogenic pathways induced by PDGF-C

Xuri Li _, Anil Kumar, Fan Zhang, Chunsik Lee, Yang Li, Zhongshu Tang and Pachiappan Arjunan

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Oncotarget. 2010; 1:309-314. https://doi.org/10.18632/oncotarget.141

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Received: July 23, 2010, Accepted: August 3, 2010, Published: August 4, 2010

VEGF is believed to be a master regulator in both developmental and pathological angiogenesis. The role of PDGF-C in angiogenesis, however, is only at the beginning of being revealed. We and others have shown that PDGF-C is a critical player in pathological angiogenesis because of its pleiotropic effects on multiple cellular targets. The angiogenic pathways induced by PDGF-C are, to a large extent, VEGF-independent. These pathways may include, but not limited to, the direct effect of PDGF-C on vascular cells, the effect of PDGF-C on tissue stroma fibroblasts, and its effect on macrophages. Taken together, the pleiotropic, versatile and VEGF-independent angiogenic nature of PDGF-C has placed it among the most important target genes for antiangiogenic therapy.


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