Sex chromosome abnormalities and psychiatric diseases
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Xinzhu Zhang1, Jian Yang2, Yuhong Li1,2, Xin Ma1,2 and Rena Li1,2,3
1 Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
2 Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China
3 Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL, USA
Rena Li, email:
Keywords: schizophrenia, autism, ADHD, depression, gender
Received: October 12, 2016 Accepted: December 07, 2016 Published: December 15, 2016
Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.
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