Research Papers: Pathology:

Medically uncontrolled conjunctival pyogenic granulomas: correlation between clinical characteristics and histological findings

Dan Wu, Tingting Qian, Takeshi Nakao, Jianjiang Xu, Zuguo Liu, Xinghuai Sun, Yiwei Chu and Jiaxu Hong _

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Oncotarget. 2017; 8:2020-2024. https://doi.org/10.18632/oncotarget.13961

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Dan Wu1,*, Tingting Qian2,*, Takeshi Nakao3, Jianjiang Xu1, Zuguo Liu4,5, Xinghuai Sun1,6, Yiwei Chu2 and Jiaxu Hong1,3,4

1 Department of Ophthalmology and Visual Science and Eye Research Institute, Eye, and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China

2 Department of Immunology, Shanghai Medical College, Fudan University, Shanghai, China

3 Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA

4 Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China

5 Eye Center and Department of Ophthalmology, The Second Xiangya Hospital and Eye Hospital, Central South University, Hunan, China

6 Key Laboratory of Myopia, National Health and Family Planning Commission, Shanghai, China

* These authors have contributed equally to this paper

Correspondence to:

Jiaxu Hong, email:

Yiwei Chu, email:

Keywords: pyogenic granulomas; clinical characteristic; histology; Pathology Section

Received: September 18, 2016 Accepted: December 07, 2016 Published: December 19, 2016


Background: Conjunctival pyogenic granulomas are commonly seen after ocular surgeries or at an ocular wound site. The aim of this study is to describe a novel histological classification for medically uncontrolled conjunctival pyogenic granulomas (MUCPG), and to explore whether the diversity in clinical features correlates to different histological subtypes of MUCPG.

Methods: This is an observational cross-section case series. We reviewed 46 consecutive patients with conjunctival pyogenic granulomas who did not respond to topical corticosteroids and underwent surgical excision from January 1, 2006 through December 31, 2015. Clinical features and histological findings were presented and analyzed.

Results: Ocular surgery, accidental injury, and chalazion were the main predisposing causes of MUCPG. The lesions tended to occur unilaterally on the bulbar conjunctiva. Forty patients (87%) presented an enrichment of inflammatory cells and proliferated capillaries in their pathological sections (inflammatory pattern). Six patients (13%) showed relatively few inflammatory cells and capillaries within fibrous stroma (fibrous pattern). Patients with the inflammatory pattern were older (p = 0.025) and tended to be located in bulbar conjunctiva (p = 0.002). The predisposing causes were also different between two histological subtypes (p = 0.007).

Conclusions: We found the correlation between clinical presentation and histological subtypes in patients with MUCPG, indicating this disease may need a new classification scheme.

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