Oncotarget

Reviews:

The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity

Ming-xin Cao, Ya-ping Jiang, Ya-ling Tang and Xin-hua Liang _

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Oncotarget. 2017; 8:12472-12483. https://doi.org/10.18632/oncotarget.13957

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Abstract

Ming-xin Cao1,2, Ya-ping Jiang3, Ya-ling Tang1,4 and Xin-hua Liang1,2

1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China

2 Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China

3 Department of Implant, The Affiliated Hospital of Qingdao University, Qingdao,Shandong, People’s Republic of China

4 Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People’s Republic of China

Correspondence to:

Xin-hua Liang, email:

Ya-ling Tang, email:

Keywords: lncRNA, microRNA, epithelial-mesenchymal plasticity, cancer metastasis

Received: October 15, 2016 Accepted: December 12, 2016 Published: December 15, 2016

Abstract

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelial-mesenchymal transition (EMT). This review summarizes the types of lncRNA-miRNA crosstalk identified to-date and discusses their influence on the epithelial-mesenchymal plasticity and clinical metastatic implication.


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