Research Papers:

HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study

Jiliang Qiu, Weiqun Lu, Nanrong Yu, Guohua Yang, Yi Li, Zhiliang Huang, Jianchang Li, Kefei Li, Houwei Xu, Shicai Chen, Xiang Zeng and Haiying Liu _

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Oncotarget. 2017; 8:4218-4227. https://doi.org/10.18632/oncotarget.13906

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Jiliang Qiu1,*, Weiqun Lu1,*, Nanrong Yu1, Guohua Yang1, Yi Li2, Zhiliang Huang1, Jianchang Li1, Kefei Li1, Houwei Xu1, Shicai Chen1, Xiang Zeng1 and Haiying Liu1

1 Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China

2 Department of Surgery, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China

* These authors have contributed equally to this paper

Correspondence to:

Haiying Liu, email:

Keywords: hepatocellular carcinoma, hepatic resection, HabibTM 4X, clamp-crush, complication

Received: July 13, 2016 Accepted: December 01, 2016 Published: December 11, 2016


Long term outcome of ablation-assisted hepatic resection is unclear for hepatocellular carcinoma (HCC) patients. This study was scheduled to compare the outcome of Habib 4X ablation assisted resection (Habib group) with clamp-crush resection (CC group) for HCC. In this study, we retrospectively enrolled 81 patients from the Habib group and 103 patients from the CC group. Oncologic outcomes were analyzed using a propensity score matching (PSM) method. Compared with the CC group, the Habib group had higher levels of γ-glutamyltransferase (P=0.044) and albumin (P=0.001), larger tumor sizes (P=0.007), shorter operation times (P=0.001), less blood loss (P=0.005), and less blood transfusions (P=0.038). There were no significant differences in complications (P=0.310), recurrence-free survival rates (RFS, P=0.112), or overall survival rates (OS, P=0.203) between the two groups. For the 67 patient pairs selected from the PSM analysis, the Habib group had better RFS and OS (P=0.033 and P=0.014, respectively). A Cox proportional hazards analysis revealed that Habib-assisted resection was an independent factor for RFS and OS (P=0.008 and P=0.016, respectively). Furthermore, for the 42 patients with central and large tumors, the Habib group had better RFS and OS than the CC group (P=0.035 and P=0.038, respectively). However, the differences of RFS and OS (P=0.117 and P=0.126, respectively) were not significant among 92 patients with peripheral or small tumors. Hence, HabibTM 4X-assisted resection is safe and provides better survival for HCC patients, particularly those with central and large tumors.

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