Research Papers:
The preexisting population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
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Carmine Onofrillo1, Alice Galbiati1, Lorenzo Montanaro1, Massimo Derenzini1
1Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy
Correspondence to:
Carmine Onofrillo, email: [email protected]
Keywords: ribosome biogenesis inhibition, 5S rRNA, ribosomal proteins, MDM2, p53
Received: December 16, 2015 Accepted: December 03, 2016 Published: December 09, 2016
ABSTRACT
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.