Oncotarget

Research Papers:

Positive regulation of TAZ expression by EBV-LMP1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma

Jiang He _, Feiyu Tang, Liyu Liu, Lin Chen, Jiang Li, Danming Ou, Lu Zhang, Zhi Li, Deyun Feng, Wenzheng Li and Lun-Quan Sun

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Oncotarget. 2017; 8:52333-52344. https://doi.org/10.18632/oncotarget.13775

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Abstract

Jiang He1,2, Feiyu Tang1, Liyu Liu1,2, Lin Chen1, Jiang Li1, Danming Ou1, Lu Zhang1,2, Zhi Li1,2, Deyun Feng3, Wenzheng Li4 and Lun-Quan Sun1,2

1Center for Molecular Medicine, Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, 410008, China

2Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China

3Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, China

4Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China

Correspondence to:

Lun-Quan Sun, email: lunquansun@csu.edu.cn

Wenzheng Li, email: wenzheng727@163.com

Keywords: EBV, LMP1, TAZ, nasopharyngeal carcinoma

Received: September 27, 2016     Accepted: November 20, 2016     Published: December 02, 2016

ABSTRACT

The Epstein-Barr virus latent membrane protein 1 (LMP1) is an integral membrane protein. LMP1 has been reported to activate the NF-κB and mitogen-activated protein kinase pathways. However, these effects alone are unable to account for the profound oncogenic properties of LMP1. TAZ is one of the nuclear effectors of Hippo-related pathways and highly expressed in many human tumors. Here, we reported that TAZ was frequently expressed in LMP1-positive nasopharyngeal carcinoma. In NPC cell lines, we showed that LMP1 promoted TAZ expression. Gelsolin is an important inhibitor of TAZ activity. Our studies showed that LMP1 interacted with gelsolin, resulting in inhibition of Lats1/2 phosphorylation and improvement of TAZ stability. Furthermore, we revealed that TAZ is important for LMP1-mediated cell proliferation, cancer stem cell-like properties and epithelial-mesenchymal transition. These findings provide new insights into the carcinogenic roles of LMP1 and contribute to further understanding of its oncogenic mechanism.


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