Research Papers:

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Shengjie Li, Mingxi Shao, Binghua Tang, Aiping Zhang, Wenjun Cao and Xinghuai Sun _

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Oncotarget. 2017; 8:2816-2824. https://doi.org/10.18632/oncotarget.13745

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Shengjie Li1, Mingxi Shao1, Binghua Tang1, Aiping Zhang1, Wenjun Cao1,2, Xinghuai Sun2,3,4,5

1Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China

2Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China

3State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China

4Key Laboratory of Myopia, Ministry of Health (Fudan University), Shangai, China

5Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shangai, China

Correspondence to:

Wenjun Cao, email: [email protected]

Xinghuai Sun, email: [email protected]

Keywords: primary angle closure glaucoma, serum, uric acid, oxidative stress

Received: September 20, 2016     Accepted: November 23, 2016     Published: December 01, 2016


Uric acid (UA) is a major antioxidant molecule and has been hypothesized to have a protective effect on the central nervous system against oxidative damage. We prospectively investigated the serum concentration of UA in primary angle closure glaucoma (PACG), and explored the association between serum concentration of UA and the severity of PACG. Using a retrospective case-control study design, 886 PACG subjects and 994 control subjects who attended the Eye & ENT Hospital of Fudan University, were eligible for this study. Glaucoma severity was classified as mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD > 6 dB) and severe (MD > 12 dB) based on the MD (mean deviation). The levels of UA were significantly lower (p = 0.025) in PACG (0.286 ± 0.082 mmol/l) compared with control (0.295 ± 0.085 mmol/l). The mean serum UA levels were lowest in the severe group (0.281 ± 0.074 mmol/l) followed by moderate (0.282 ± 0.080 mmol/l) and mild (0.297 ± 0.090 mmol/l) with significant differences among the three groups (p = 0.032). In multivariate regression analysis, there was a significant negative correlation between UA level and vertical cup-disc ratio (B = −0.165, p = 0.035). Significantly lower serum UA concentration in PACG and its negative association with disease severity presented it as an important candidate in reaction to oxidative stress in glaucoma pathogenesis.

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