Oncotarget

Research Papers:

GSTM1 and GSTT1 polymorphisms are associated with increased bladder cancer risk: Evidence from updated meta-analysis

Cui Yu _, Chen Hequn, Liu Longfei, Wang Long, Chen Zhi, Zeng Feng, Chen Jinbo, Li Chao and Zu Xiongbing

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Oncotarget. 2017; 8:3246-3258. https://doi.org/10.18632/oncotarget.13702

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Abstract

Cui Yu1, Chen Hequn1, Liu Longfei1, Wang Long1, Chen Zhi1, Zeng Feng1, Chen Jinbo1, Li Chao1, Zu Xiongbing1

1Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410000, China

Correspondence to:

Zu Xiongbing, email: [email protected]

Keywords: GSTM1, GSTT1, polymorphism, bladder cancer

Received: September 06, 2016    Accepted: November 16, 2016    Published: November 29, 2016

ABSTRACT

Background: Previous studies have indicated association between GSTM1 and GSTT1 gene polymorphisms and bladder cancer susceptibility, but the results have been inconclusive. Here, we performed a meta-analysis to investigate the association between GSTM1/GSTT1 deletion polymorphisms and bladder cancer susceptibility.

Methods: We searched for all studies investigating the association between GSTM1 or GSTT1 polymorphism and bladder cancer susceptibility in Pubmed, Web of Knowledge, and the Cochrane Central Search Library. A systematic review and meta-analysis were performed. Subgroup analyses were performed on different ethnicity, population-based and smoking status.

Results: Our search identified 63 studies. GSTM1 null, GSTT1 null and GSTM1/GSTT1 double-null genotypes were associated with increased risk of bladder cancer (OR: 1.36 95% CI: 1.25-1.47, P<0.01; OR: 1.13 95% CI: 1.02-1.25, P<0.01; OR: 1.84 95% CI: 1.50-2.26, P<0.01). Subgroup analyses indicated that the GSTM1-null genotype was associated with increased risk of bladder cancer in Caucasians and Asians, while the GSTT1-null genotype was associated with increased risk of bladder cancer in Caucasians. The GSTM1/GSTT1 double-null genotype was associated with increased risk of bladder cancer in Caucasians, Asians, and Africans. Stratified analyses of population-based associations indicated increased bladder cancer risk associated with GSTM1-null and GSTM1/GSTT1 double-null genotypes in hospital-based and population-based studies. GSTM1 deletion was associated with increased bladder cancer risk in both smokers and nonsmokers. Non-smokers with the GSTM1/GSTT1 double-null genotype had an increased bladder cancer risk.

Conclusion: This meta-analysis demonstrates that the GSTM1-null, GSTT1-null, and GSTM1/GSTT1 double-null genotypes are associated with increased bladder cancer risk.


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