Oncotarget

Research Papers:

Risk stratification of thyroid nodules with Bethesda category III results on fine-needle aspiration cytology: The additional value of acoustic radiation force impulse elastography

Chong-Ke Zhao, Hui-Xiong Xu _, Jun-Mei Xu, Cheng-Yu Sun, Wei Chen, Bo-Ji Liu, Xiao-Wan Bo, Dan Wang and Shen Qu

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Oncotarget. 2017; 8:1580-1592. https://doi.org/10.18632/oncotarget.13685

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Abstract

Chong-Ke Zhao1,2,3, Hui-Xiong Xu1,2,3, Jun-Mei Xu1,2,3, Cheng-Yu Sun1,2,3, Wei Chen1,2,3, Bo-Ji Liu1,2,3, Xiao-Wan Bo1,2,3, Dan Wang1,2,3, Shen Qu4

1Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai 200072, China

2Thyroid Institute, Tongji University School of Medicine, Shanghai 200072, China

3Shanghai Center for Thyroid Diseases, Shanghai 200072, China

4Department of Endocrinology & Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China

Correspondence to:

Hui-Xiong Xu, email: [email protected]

Keywords: thyroid nodules, fine-needle aspiration cytology, Bethesda category III, ultrasound, acoustic radiation force impulse elastography

Received: August 25, 2016     Accepted: November 15, 2016     Published: November 29, 2016

ABSTRACT

To assess the value of conventional ultrasound, conventional strain elastography (CSE) and acoustic radiation force impulse (ARFI) elastography in differentiating likelihood of malignancy for Bethesda category III thyroid nodules. 103 thyroid nodules with Bethesda category III results on fine-needle aspiration cytology (FNAC) in 103 patients were included and all were pathologically confirmed after surgery. Conventional ultrasound, CSE and ARFI elastography including ARFI imaging and point shear wave speed (SWS) measurement were performed. Univariate and multivariate analyses were performed to identify the independent factors associated with malignancy. Area under the receiver operating characteristic curve (Az) was calculated to assess the diagnostic performance. Pathologically, 65 nodules were benign and 38 were malignant. Significant differences were found between benign and malignant nodules in ARFI. The cut-off points were ARFI imaging grade ≥ 4, SWS > 2.94 m/s and SWS ratio > 1.09, respectively. ARFI imaging (Az: 0.861) had the highest diagnostic performance to differentiate malignant from benign nodules, following by conventional ultrasound (Az: 0.606 - 0.744), CSE (Az: 0.660) and point SWS measurement (Az: 0.725 - 0.735). Multivariate logistic regression analysis showed that ARFI imaging grade ≥ 4 was the most significant independent predictor. The combination of ARFI imaging with point SWS measurement significantly improved the specificity (100% vs. 80.0%) and positive predictive value (100 % vs. 72.9%) in comparison with ARFI imaging alone. ARFI elastography is a useful tool in differentiating malignant from benign thyroid nodules with Bethesda category III results on FNAC.


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