Oncotarget

Research Papers:

Long non-coding RNA SPRY4-IT1 promotes gallbladder carcinoma progression

Liang Yang, Xi Cheng, Naijian Ge, Weixing Guo _, Feiling Feng and Fuying Wan

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Oncotarget. 2017; 8:3104-3110. https://doi.org/10.18632/oncotarget.13621

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Abstract

Liang Yang1,*, Xi Cheng1,*, Naijian Ge2, Weixing Guo3, Feiling Feng4, Fuying Wan1

1Radiation Center, East Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 201805, China

2Mini-Invasive Intervention Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China

3Hepatic Surgical Department VI, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, China

4Department of Biliary Tract, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China

*Liang Yang, Xi Cheng and Naikian Ge contributed equally to this work

Correspondence to:

Weixing Guo, email: [email protected]

Feiling Feng, email: [email protected]

Keywords: SPRY4-IT1, lncRNA, GBC, metastasis, EMT

Received: September 20, 2016     Accepted: October 24, 2016     Published: November 25, 2016

ABSTRACT

Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. Long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including GBC. SPRY4-IT1 has been recently revealed as oncogenic regulator in many cancers. However, whether SPRY4-IT1 is involved in GBC progression remains largely unknown. To investigate the role of SPRY4-IT1 in GBC, we evaluated the expression SPRY4-IT1 in GBC tissues and cell lines, and investigated the effect of SPRY4-IT1 knockdown on cell proliferation, migration and invasion of GBC in vitro. Our result showed that SPRY4-IT1 was upregulated in GBC tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited GBC cell proliferation. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for GBC, and may be served as a candidate target for new therapies in human GBC.


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