Oncotarget

Research Papers:

MiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case-control studies

Zhaolan Xiang, Jue Song, Xianlu Zhuo, Qi Li and Xueyuan Zhang _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:1226-1233. https://doi.org/10.18632/oncotarget.13599

Metrics: PDF 1616 views  |   HTML 2402 views  |   ?  


Abstract

Zhaolan Xiang1, Jue Song2, Xianlu Zhuo1, Qi Li1, Xueyuan Zhang1

1Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China

2Affiliated Hospital of Guizhou Medical University, Guiyang, China

Correspondence to:

Xianlu Zhuo, email: [email protected]

Xueyuan Zhang, email: [email protected]

Keywords: miR-146a, head & neck cancer, susceptibility, meta-analysis, polymorphism

Received: September 16, 2016    Accepted: November 08, 2016    Published: November 25, 2016

ABSTRACT

Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then essential data were extracted for data analysis. Next, subgroup analyses on ethnicity, source of controls, sample size, and genotyping method were also carried out. As a result, a total of 9 publications involving 10 independent case-control studies were included. The overall data indicated a significant association between miR-146a rs2910164 polymorphism and HNC risk [C vs. G: odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.00–1.31; CC+CG vs. GG: OR=1.21; 95%CI=1.02-1.43]. Variant alleles of miR-146a rs2910164 may have a correlation with increased HNC risk. Future well-designed studies containing large sample sizes are needed to verify this result.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13599