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Research Papers:

Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan

Daisuke Kawakita _, Yuichiro Tada, Yorihisa Imanishi, Shintaro Beppu, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Akira Shimizu, Yukiko Sato, Chihiro Fushimi, Soichiro Takase, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Tomotaka Shimura, Toyoyuki Hanazawa, Shingo Murakami and Toshitaka Nagao

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Oncotarget. 2017; 8:1083-1091. https://doi.org/10.18632/oncotarget.13565

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Abstract

Daisuke Kawakita1, Yuichiro Tada2, Yorihisa Imanishi3, Shintaro Beppu1, Kiyoaki Tsukahara4, Satoshi Kano5, Hiroyuki Ozawa3, Kenji Okami6, Yuichiro Sato7, Akira Shimizu4, Yukiko Sato8, Chihiro Fushimi2, Soichiro Takase4, Takuro Okada2, Hiroki Sato4, Kuninori Otsuka3, Yoshihiro Watanabe3, Akihiro Sakai6, Koji Ebisumoto6, Takafumi Togashi7, Yushi Ueki7, Hisayuki Ota7, Tomotaka Shimura9, Toyoyuki Hanazawa10, Shingo Murakami1, Toshitaka Nagao9

1Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan

3Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan

4Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan

5Department of Otorhinolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan

6Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan

7Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan

8Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

9Department of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo, Japan

10Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

Correspondence to:

Daisuke Kawakita, email: [email protected]

Keywords: salivary duct carcinoma, survival, mGPS, CRP, NLR

Received: August 26, 2016     Accepted: November 09, 2016     Published: November 24, 2016

ABSTRACT

The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.


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