Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan
Metrics: PDF 927 views | HTML 1306 views | ?
Daisuke Kawakita1, Yuichiro Tada2, Yorihisa Imanishi3, Shintaro Beppu1, Kiyoaki Tsukahara4, Satoshi Kano5, Hiroyuki Ozawa3, Kenji Okami6, Yuichiro Sato7, Akira Shimizu4, Yukiko Sato8, Chihiro Fushimi2, Soichiro Takase4, Takuro Okada2, Hiroki Sato4, Kuninori Otsuka3, Yoshihiro Watanabe3, Akihiro Sakai6, Koji Ebisumoto6, Takafumi Togashi7, Yushi Ueki7, Hisayuki Ota7, Tomotaka Shimura9, Toyoyuki Hanazawa10, Shingo Murakami1, Toshitaka Nagao9
1Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan
3Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
4Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan
5Department of Otorhinolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
6Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan
7Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan
8Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
9Department of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo, Japan
10Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Daisuke Kawakita, email: email@example.com
Keywords: salivary duct carcinoma, survival, mGPS, CRP, NLR
Received: August 26, 2016 Accepted: November 09, 2016 Published: November 24, 2016
The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.