Oncotarget

Research Papers:

MYC associated zinc finger protein promotes the invasion and metastasis of hepatocellular carcinoma by inducing epithelial mesenchymal transition

Wei Luo, Xiaonian Zhu, Wei Liu, Yuan Ren, Chunhua Bei, Linyuan Qin, Xueyan Miao, Fen Tang, Guifang Tang and Shengkui Tan _

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Oncotarget. 2016; 7:86420-86432. https://doi.org/10.18632/oncotarget.13416

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Abstract

Wei Luo1,*, Xiaonian Zhu1,*, Wei Liu1, Yuan Ren1, Chunhua Bei1, Linyuan Qin1, Xueyan Miao1, Fen Tang2, Guifang Tang2, Shengkui Tan1

1School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, People’s Republic of China

2Department of Hepatology, The Affiliated Nanxishan Hospital of Guilin Medical University, Guilin 541004, Guangxi, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Shengkui Tan, email: [email protected]

Keywords: MYC associated zinc finger protein (MAZ), hepatocellular carcinoma (HCC), zinc finger E-box binding homeobox 1 (ZEB1), zinc finger E-box binding homeobox 2 (ZEB2), epithelial-mesenchymal transition (EMT)

Received: July 11, 2016     Accepted: November 09, 2016     Published: November 16, 2016

ABSTRACT

MYC associated zinc finger protein (MAZ) plays a key role in regulation of gene expression and tumor development. Studies have shown that deregulated expression of MAZ is closely related to the progression of tumors such as glioblastoma, breast cancer, prostate cancer and liposarcoma. However, the role of MAZ in hepatocellular carcinoma (HCC) has not been fully elucidated. Here, we found that expression of MAZ was increased in HCC and correlated to the distant metastasis of HCC. Moreover, we found that MAZ had a relationship with zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), two important mesenchymal markers in epithelial-mesenchymal transition (EMT) that were over-expressed in HCC. After knocking-down MAZ expression in HCC cell lines using RNA interruption, HCC cell proliferation, tumorigenesis, invasion and migration were significantly inhibited. In addition, we found that expression of other EMT markers was also changed besides ZEB1 and ZEB2 by decreasing MAZ expression, both detected in vivo and in vitro assays. Therefore, we conclude that MAZ can promote the invasion and metastasis of HCC by inducing EMT.


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