Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population
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Xu Li1,2,*, Wenjing Zou3,*, Ming Liu4, Wei Cao5, Yonghong Jiang6, Gaili An7, Yuzheng Wang2, Shangke Huang1, Xinhan Zhao1
1Department of Oncology, First Affiliated Hospital, Xi’an Jiatong University, Xi’an, Shannxi 710061, China
2Department of The First of Internal Medicine, Tumor Hospital of Shaanxi Province Affiliated Hospital, Medical College of Xi’an Jiao Tong University, Xi’an, Shannxi 710061, China
3Department of The Fifth of Internal Medicine, Xi’an No5 Hospital, Xi’an, Shannxi 710082, China
4Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xi’an Jiatong University, Xi’an, Shannxi 710003, China
5Department of Oncological Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, China
6Department of Oncological Surgery, Weinan Central Hospital, Weinan, Shaanxi 714000, China
7Department of Oncology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China
*The authors are joint first authors
Xinhan Zhao, email: [email protected]
Keywords: breast cancer, single nucleotide polymorphism (SNP), case-control study, Chinese population
Received: July 27, 2016 Accepted: October 19, 2016 Published: November 16, 2016
We selected 13 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with breast cancer risk in the Chinese Han population. Upon statistical analyses of clinical data from 551 patients and 577 controls, we found that six of the 13 SNPs were associated with breast cancer; namely, rs4973768(Odds ratio (OR) = 1.30, 95% confidence interval (CI) =1.01-1.67), rs981782(OR =1.30, 95% CI=1.01-1.66), rs1432679(OR =0.84, 95% CI=0.70-0.99), rs10759243(OR=1.30, 95%CI=1.09-1.55), rs10822013(OR =1.18, 95% CI=1.00-1.39) and rs704010(OR =1.63, 95% CI=1.04-2.56). When stratified based on breast cancer subtype, our analyses revealed that three SNPs (rs981782, rs10759243 and rs704010) correlated with ER+ breast cancer, while another three (rs4973768, rs1432679 and rs10822013) correlated with ER- breast cancer. We obtained similar results while investigating the correlation of SNPs with PR status or clinical stage. Our results suggest that associations identified between SNPs and breast cancer through genome-wide association studies (GWAS) may not always be generalizable across races.
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