Oncotarget

Research Papers:

A promoter polymorphism in APJ gene is significantly associated with blood pressure changes and hypertension risk in Chinese women

Guofeng Li, Xingyuan Sun, Dalong Zhao, Lan He, Lihong Zheng, Jing Xue, Bin Wang and Hongming Pan _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:86257-86265. https://doi.org/10.18632/oncotarget.13370

Metrics: PDF 1759 views  |   HTML 1918 views  |   ?  


Abstract

Guofeng Li1,*, Xingyuan Sun2,*, Dalong Zhao3, Lan He4, Lihong Zheng5, Jing Xue6, Bin Wang7, Hongming Pan8

1Department of Human Anatomy, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China

2Department of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China

3Clinical Laboratory, Qiqihar Jianhua Hospital, Qiqihar, Heilongjiang, China

4Department of Advanced Mathematics, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China

5Department of Biogenetics, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China

6Department of Immunology, School of Medical Technolog, Qiqihar Medical University, Qiqihar, Heilongjiang, China

7Department of Physiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China

8Department of Biochemistry, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China

*These authors contributed equally to this work

Correspondence to:

Hongming Pan, email: [email protected] or

Bin Wang, email: [email protected]

Keywords: essential hypertension, blood pressure, apelin/APJ system, polymorphism, association

Received: October 07, 2016     Accepted: November 07, 2016     Published: November 15, 2016

ABSTRACT

The aim of this study was to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population. This is a population-based case-control study, including 650 hypertensive patients and 645 normotensive controls. Data were analyzed by STATA and Haplo.Stats. The genotype distributions of 5 study polymorphisms were in Hardy-Weinberg equilibrium in both genders. The rs7119375 and rs10501367 were completely linked. The genotypes (P = 0.001) and alleles (P < 0.001) of rs7119375 differed significantly between patients and controls in women. Carriers of rs7119375-AA genotype had significant higher systolic blood pressure (SBP) than carriers of rs7119375-GG genotype in both patients and controls of female gender (P < 0.01). Moreover, carriers of rs7119375-A allele were 1.80 times more likely to develop hypertension relative to carriers of rs7119375-GG genotype after adjusting for age, body mass index and glucose (odds ratio: 1.80; 95% confidence interval: 1.03–3.16; P = 0.040). Further allele combination analysis supported the leading contribution of rs7119375 to hypertension risk. Our findings demonstrated that the mutation of promoter polymorphism rs7119375 in APJ gene was significantly associated with elevated SBP and increased hypertension risk in Chinese women.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 13370