Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ
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Xia Qiu1,4,*, Jianguo Jiao2,*, Yidong Li3,*, Tian Tian1,3
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
2Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
3Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
4Department of Medicine, Shangqiu Medical School, Shangqiu, Henan Province, China
*These authors contributed equally to this work
Tian Tian, email: [email protected]
Keywords: FZD7, TAZ, glioma, cell proliferation, prognosis
Received: September 01, 2016 Accepted: November 03, 2016 Published: November 11, 2016
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasm in the central nervous system. Frizzled-7 (FZD7) is a seven-pass trans-membrane Wnt receptor that plays a critical role in the development of various tumors. In this study, we detected high-level FZD7 expression in glioma and its overexpression was associated with advanced tumor stage. In vitro functional assays showed that forced overexpression of FZD7 promoted proliferation of gliomas cells, whereas knockdown of endogenous FZD7 significantly suppressed proliferation ability of these cells. In a xenograft assay, FZD7 was also found to promote the growth of glioma cells. We further found that FZD7 could activate transcriptional coactivator with PDZ-binding motif (TAZ), and TAZ was required for FZD7 to promote cell proliferation in glioma. Furthermore, the univariate analysis of survival shows that glioma patients with high FZD7 expression have a shorter survival. In conclusion, our findings demonstrate that FZD7 may promote glioma cell proliferation via upregulation of TAZ.
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