Tumor specific delivery and therapy mediate by integrin β6-target immunoliposomes for β6-siRNA in colon carcinoma
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Liu Song1, Zhang Fan2, Niu Jun3, Liang Benjia3, Li Zequn3, Wang Xilong1, Jia Zhongming1, Han yong1, Wang Xiaohong1, Cheng Kai1, Yang Zhenlin1
1Department of Thyroid & Breast Surgery, Binzhou Medical College Affiliated Hospital, Binzhou 256600, Shandong, PR China
2Department of Oncology, Binzhou Medical College Affiliated Hospital, Binzhou 256600, Shandong, PR China
3Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, PR China
Yang Zhenlin, email: [email protected]
Keywords: colon carcinoma, integrinβ6, target therapy, immunoliposomes, siRNA
Received: June 06, 2016 Accepted: October 21, 2016 Published: November 08, 2016
Adjuvant chemotherapy does not achieve the desired therapeutic efficacy in colon cancer as a result of the deficient reaction. Gene therapy using small interfering RNAs (siRNAs) delivered by target delivering system represents a potent and specific strategy in tumor therapy. Integrinβ6 is exclusively expressed in malignant colonic epithelia, associated with the progression, metastasis, and chemotherapeutic resistance of colon cancer. Accordingly, designing an efficient and targeted delivery system for β6-siRNA could be a potential approach to improve therapeutic efficacy of colon cancer. Here, we designed the Integrinβ6 target immunoliposomes for highly efficient and selective delivery of β6-siRNA in colon cancer, which consequently resulted in greatly growth suppression, invasion and metastasis of colon cancer cells. Moreover, it was able to greatly inhibit the tumor growing in vivo.
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