Transcriptional repression of FOXO1 by KLF4 contributes to glioma progression
Metrics: PDF 2110 views | HTML 2340 views | ?
Guodong Tang1, Dingyang Liu1,2, Gelei Xiao1, Qing Liu1,2, Jian Yuan1,2
1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
2The Institute of Skull Base Surgery and Neurooncology at Hunan Province, Changsha 410008, Hunan, China
Qing Liu, email: [email protected]
Jian Yuan, email: [email protected]
Keywords: glioma, FOXO1, progression, KLF4, transcriptional regulation
Received: September 16, 2016 Accepted: October 19, 2016 Published: November 07, 2016
In this study, our findings indicated that FOXO1 expression frequently decreased in glioma tissues and cells. FOXO1 expression decrease correlated with glioma progression and predicted a worse overall survival of glioma patients. Restored FOXO1 expression inhibited glioma cells invasion and suppressed glioma cells proliferation in vitro and growth in vivo. Additionally, we found that KLF4 expression frequently increased in glioma tissues and negatively correlated with FOXO1 expression. Bioinformatics analysis and experimental results indicated that KLF4 transcriptionally repressed FOXO1 expression in glioma cells. Moreover, KLF4 expression increase correlated with glioma progression and predicted a poorer overall survival of glioma patients. KLF4 knockdown attenuated glioma cells invasion and growth. These data provide a rationale for targeted intervention on KLF4-FOXO1 signaling pathway to suppress glioma progression.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.