Oncotarget

Research Papers:

Prognostic nutritional index predicts short-term outcomes after liver resection for hepatocellular carcinoma within the Milan criteria

Mengyun Ke _, Tao Xu, Na Li, Yifan Ren, Aihua Shi, Yi Lv and Haiqi He

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Oncotarget. 2016; 7:81611-81620. https://doi.org/10.18632/oncotarget.13151

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Abstract

Mengyun Ke1,*, Tao Xu2,*, Na Li3, Yifan Ren4, Aihua Shi1, Yi Lv1,4, Haiqi He1,5

1Research Institute of Advanced Surgical Techniques and Engineering, Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

2Department of Hepatobiliary Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China

3Department of Laboratory Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

4Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

5Department of thoracic surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

*These authors have contributed equally to this work

Correspondence to:

Haiqi He, email: hhq823@mail.xjtu.edu.cn

Keywords: hepatocellular carcinoma, hepatectomy, postoperative complications, prognostic nutritional index

Received: July 11, 2016    Accepted: October 13, 2016    Published: November 07, 2016

ABSTRACT

Background: The prognostic nutritional index (PNI) is calculated based on the serum albumin concentration and the total lymphocyte count. The aim of this study was to investigate the prognostic ability of the PNI for postoperative complications after liver resection to treat hepatocellular carcinoma (HCC) within the Milan criteria.

Results: Postoperative complications were observed in 166 (44.6%) patients. The optimal cutoff value of the PNI was set at 45.6 for postoperative complications. Patients in the PNI-low (PNI < 45.6) group were more likely to have postoperative complications, more blood loss, a longer surgery time and a longer hospital stay than patients in the PNI-high group (PNI > 45.6). Our regression analysis demonstrated that the preoperative PNI and albumin-bilirubin (ALBI) score were significantly associated with postoperative complications (Pearson correlation coefficient, -0.865, p < 0.001). The multivariate analysis revealed that the PNI was an independent predictor of postoperative complications.

Materials and Methods: Three-hundred and seventy-two patients who underwent partial hepatectomy for HCC from 2003 to 2014 were identified. The cutoff value of the PNI was determined by a receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to identify clinicopathological features associated with postoperative complications.

Conclusion: The PNI may be a significant prognostic factor for evaluating short-term outcomes of patients with HCC after partial hepatectomy.


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