Oncotarget

Research Papers:

Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies

Sumei Chen, Yuanyuan Chen, Shenglin Ma, Ruzhen Zheng, Pengjun Zhao, Lidan Zhang, Yuehua Liu, Qingqing Yu, Qinghua Deng and Ke Zhang _

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Oncotarget. 2016; 7:80980-80989. https://doi.org/10.18632/oncotarget.13140

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Abstract

Sumei Chen1,*, Yuanyuan Chen1,*, Shenglin Ma2,3, Ruzhen Zheng1, Pengjun Zhao1, Lidan Zhang1, Yuehua Liu1, Qingqing Yu1, Qinghua Deng1,2, Ke Zhang1

1Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310002, China

2Affiliated Hangzhou First People’s Hospital, Hangzhou, Zhejiang 310006, China

3Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, Zhejiang 310006, China

*These authors contributed equally to this work

Correspondence to:

Ke Zhang, email: scitificwork@163.com

Qinghua Deng, email: wordhail@163.com

Keywords: breast cancer, dietary fibre, meta-analysis, epidemiology

Received: July 05, 2016     Accepted: October 27, 2016     Published: November 05, 2016

ABSTRACT

Current evidence from randomised controlled trials on the effects of dietary fibre intake on breast cancer risk is inconsistent. We conducted a meta-analysis to determine the effectiveness of dietary fibre intake in reducing breast cancer risk. We searched for prospective and case-control studies on dietary fibre intake and breast cancer risk in the English language through March 2016. Twenty-four epidemiologic studies obtained through the PubMed, Embase, Web of Science, and Cochrane Library databases were systematically reviewed. A random-effects model was used to compute the pooled risk estimates by extracting the risk estimate of the highest and lowest reported categories of intake from each study. The meta-analyses showed a 12% decrease in breast cancer risk with dietary fibre intake. The association between dietary fibre intake and breast cancer risk was significant when stratified according to Jadad scores, study types, and menopause status. Dose-response analysis showed that every 10 g/d increment in dietary fibre intake was associated with a 4% reduction in breast cancer risk, and little evidence of publication bias was found. Thus, dietary fibre consumption is significantly associated with a reduced risk of breast cancer, particularly in postmenopausal women.


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