Oncotarget

Research Papers:

Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population

Xianglong Duan, Wei Cao, Lijie Wang, Sida Liu, Zhao Liu, Bolun Zhang, Hua Yang, Tian Feng, Jiayi Zhang, Xiyang Zhang, Yanbin Long and Tianbo Jin _

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Oncotarget. 2016; 7:82727-82732. https://doi.org/10.18632/oncotarget.13102

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Abstract

Xianglong Duan1,*, Wei Cao2,*, Lijie Wang3, Sida Liu1, Zhao Liu4, Bolun Zhang5, Hua Yang6, Tian Feng6, Jiayi Zhang7, Xiyang Zhang7, Yanbin Long1, Tianbo Jin6,7,8

1Department of the Second General Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, China

2Department of Oncological Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, China

3Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China

4Department of Surgery, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China

5Graduate School of Inner Mongolia Medical University, Hohhot 010030, China

6Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China

7School of Life Sciences, Northwest University, Xi’an 710069, China

8Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China

*Joint first authors

Correspondence to:

Tianbo Jin, email: jintianbo@gmail.com

Yanbin Long, email: longyanbinshaanxi@163.com

Keywords: gastric cancer (GC), telomerase reverse transcriptase (TERT), single nucleotide polymorphisms (SNP)

Received: May 15, 2016     Accepted: September 16, 2016     Published: November 04, 2016

ABSTRACT

Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at Chr5p15.33, which is associated with multiple cancer types. In this study, we validated the association between TERT polymorphisms and gastric cancer (GC) risk with a case-control study in a Chinese Han population. A total of 302 GC patients and 300 control individuals were recruited. We identified three single nucleotide polymorphisms (SNPs) in TERT that were associated with GC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models after adjusting for age and gender to assess the association. The minor alleles of three SNPs were associated with increased GC risk inallelic model analysis. For two of the SNPs, rs10069690 and rs2853676,, the dominant and additive model frequencies were higher in GC cases compared to controls. Further haplotype analysis revealed a protective effect of haplotype ‘‘CG’’ of the TERT gene, while the haplotype “TA” increased GC risk.Our resultsprovide new evidence for the association between TERT and GC susceptibility in the Chinese Han population.


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