Oncotarget

Research Papers:

Autophagy as an emerging therapy target for ovarian carcinoma

Lei Zhan _, Yu Zhang, Wenyan Wang, Enxue Song, Yijun Fan, Jun Li and Bing Wei

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Oncotarget. 2016; 7:83476-83487. https://doi.org/10.18632/oncotarget.13080

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Abstract

Lei Zhan1, Yu Zhang1, Wenyan Wang1, Enxue Song1, Yijun Fan1, Jun Li2,*, Bing Wei1

1Department of gynecology and obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China

2School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China

*Co-corresponding author

Correspondence to:

Bing Wei, email: m1351565@163.com, weibing1965@163.com

Keywords: autophagy, dual functions, ovarian carcinoma, mechanism, therapies

Received: June 21, 2016    Accepted: September 21, 2016    Published: November 04, 2016

ABSTRACT

Autophagy is a conserved cellular self-digestion pathway for maintenance of homeostasis under basal and stressed conditions. Autophagy plays pivotal roles in the pathogenesis of many diseases, such as aging-related diseases, autoimmune diseases, cardiovascular diseases, and cancers. Of special note is that accumulating data suggest an intimate relationship between autophagy and ovarian carcinoma. Autophagy is well identified to act as either as a tumor-suppressor or as a tumor-promoter in ovarian carcinoma. The exact function of autophagy in ovarian carcinoma is highly dependent on the circumstances of cancer including hypoxic, nutrient-deficient, chemotherapy and so on. However, the mechanism underlying autophagy associated with ovarian carcinoma remains elusive, the precise role of autophagy in ovarian carcinoma also remains undetermined. In this review, we tried to sum up and discuss recent research achievements of autophagy in ovarian cancer. Moreover, waves of novel therapies ways for ovarian carcinoma based on the functions of autophagy were collected.


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PII: 13080