Research Papers:

Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis

Fang-teng Liu _, Hua Pan, Guang-feng Xia, Cheng Qiu and Zheng-ming Zhu

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2016; 7:83177-83186. https://doi.org/10.18632/oncotarget.13076

Metrics: PDF 2915 views  |   HTML 2834 views  |   ?  


Fang-teng Liu1, Hua Pan1, Guang-feng Xia1, Cheng Qiu1, Zheng-ming Zhu1

1Department of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, P. R. China

Correspondence to:

Zheng-ming Zhu, email: [email protected]

Keywords: long noncoding RNA, H19, carcinoma, prognosis, meta-analysis

Received: April 29, 2016    Accepted: October 17, 2016    Published: November 4, 2016


Background: Many studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development. An increased level of H19 was also associated with poor clinical outcomes of cancer patients.

Results: 12 eligible studies were screened, with a total of 1437 cancer patients. From the results of meta-analysis, as for prognosis, the patients with high expression of lncRNA H19 were shorter in OS (HR=1.08, 95% CI: 1.05-1.12). Statistical significance was also showed in subgroup meta-analysis stratified by the cancer type, analysis type and sample size. In addition, the patients detected with high H19 expression may be poorer in DFS (HR=1.27; 95% CI = 0.97-1.56). As for clinicopathology, it showed that increased H19 was related to poor histological grades (OR=2.31, 95% CI: 1.12-4.75), positive lymph node metastasis (OR=2.29, 95 % CI: 1.21-4.34) and advanced clinical stage (OR=4.83, 95% CI: 3.16-7.39).

Materials and Methods: Eligible studies were collected by retrieving keywords in PubMed, Web of Science, Embase, CNKI and Wanfang database, from 1966 to April 23, 2016. This quantitative meta-analysis was performed with Stata SE12.0 and RevMan5.3 software. It aimed to explore the association between H19 expression level and prognosis and clinicopathology.

Conclusions: LncRNA-H19 may be a novel molecular marker for predicting solid tumors. It can also be a predictive factor of clinicopathological features in various cancers. Further studies are needed to verify the clinical utility of H19 in human cancers.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13076