Clinical Research Papers:

Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer’s disease patients

Junwu Zhao, Zhenguang Li, Yannan Cong, Jinbiao Zhang, Ming Tan, Haixia Zhang, Na Geng, Mengfan Li, Wenwen Yu and Peiyan Shan _

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Oncotarget. 2017; 8:33864-33871. https://doi.org/10.18632/oncotarget.13060

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Junwu Zhao1,2, Zhenguang Li2, Yannan Cong2, Jinbiao Zhang2, Ming Tan2, Haixia Zhang2, Na Geng2, Mengfan Li2, Wenwen Yu3 and Peiyan Shan1

1 Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China

2 Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China

3 Department of Clinical Medicine (Neurology), Weifang Medical University, Weifang, Shandong, China

Correspondence to:

Peiyan Shan, email:

Keywords: rTMS, cognitive function, AD

Received: September 12, 2016 Accepted: October 24, 2016 Published: November 03, 2016


Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer’s disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention. In this work, data from 30 AD patients revealed that there was no obvious interaction effect of time-by-group. The ADAS-cog, MMSE and WHO-UCLA AVLT score in the rTMS group was significantly improved compared with baselines at 6 weeks after treatment (all p<0.05). Meanwhile, MoCA scores were also obviously ameliorated in the mild AD patients with rTMS. Besides, subgroup analysis showed that the effect of rTMS on the memory and language of mild AD patients was superior to those of moderate AD patients. In conclusion, our findings suggested that repetitive transcranial magnetic stimulation improves cognitive function, memory and language level of AD patients, especially in the mild stage of AD. Thus, rTMS can be recommended as a promising adjuvant therapy combined with cholinesterase inhibitors at the mild stage of AD patients.

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