Research Papers:

Risk of lung cancer in Parkinson’s disease

Xin Xie, Xiaoguang Luo _, Mingliang Xie, Yang Liu and Ting Wu

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Oncotarget. 2016; 7:77319-77325. https://doi.org/10.18632/oncotarget.12964

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Xin Xie1, Xiaoguang Luo1, Mingliang Xie2, Yang Liu1, Ting Wu1

1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang City 110001, PR China

2Clinics of the People’s Armed Police Command College, Tianjin City, 300000, PR China

Correspondence to:

Xiaoguang Luo, email: [email protected]

Keywords: lung neoplasms, meta-analysis, Parkinson’s disease, risk

Received: September 14, 2016     Accepted: October 14, 2016     Published: October 27, 2016


Recently, growing evidence has revealed the significant association between Parkinson’s disease (PD) and cancer. However, controversy still exists concerning the association between PD and lung cancer. A comprehensive article search for relevant studies published was performed using the following online databases: PubMed, Web of Science and Embase up to August 31, 2016. The pooled risk ratio (RR) and their 95 % confidence intervals (CI) were calculated using the method of inverse variance with the random-effects model. Fifteen studies comprising 348,780 PD patients were included in this study. The pooled result indicated that patients with PD were significantly associated with a decreased risk of lung cancer (RR: 0.53, 95% CI: 0.41−0.70, P < 0.001). In addition, subgroup analyses performed in Western population also confirmed the significant inverse relationship between PD and risk of lung cancer (RR: 0.48, 95% CI: 0.39−0.60, P < 0.001). In the subgroup analysis, a reduced risk of lung cancer in PD patients from Western population was consistent regardless of study design, gender, or study quality. In conclusion, PD patients were significantly associated with a reduced risk of lung cancer in Western population. The relationship between them in Asian population needs to be confirmed by future studies.

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