Clinical Research Papers:

Intraoperative radiotherapy for the treatment of thyroid cancer: a pilot study

Pei-Qiang Yi, Fang-Fang Nie, You-Ben Fan, Wei-Wei Yu, Chao-Su Hu, Xiao-Mao Guo and Jie Fu _

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Oncotarget. 2017; 8:29355-29360. https://doi.org/10.18632/oncotarget.12901

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Pei-Qiang Yi1,*, Fang-Fang Nie1,*, You-Ben Fan5, Wei-Wei Yu1, Chao-Su Hu2,3, Xiao-Mao Guo2,4 and Jie Fu1

1 Department of Radiation Oncology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China

2 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

3 Department of Oncology, Shanghai Medical College, Shanghai, China

4 Shanghai Medical College, Fudan University, Shanghai, China

5 Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Jie Fu, email:

Chao-su Hu, email:

Xiao-Mao Guo, email:

Keywords: thyroid cancer, intraoperative radiotherapy, pilot study, radiation therapy, adverse reactions

Received: August 04, 2016 Accepted: October 14, 2016 Published: October 25, 2016


We preliminarily evaluated the clinical feasibility and efficacy of intraoperative radiotherapy in patients with thyroid carcinoma. Nine thyroid cancer patients received intraoperative radiotherapy using an Intrabeam system. The dose was 3-4 Gy and the irradiation time ranged from 1 min 32 s to 7 min 33s. One case was a primary thyroid carcinoma, while the other cases were recurrent disease. Adverse effects, recurrence and survival were analyzed. In one patient, poorly differentiated thyroid carcinoma recurred 5 months after treatment, one patient developed a postoperative tracheal skin fistula, and one patient developed a wound infection. Because the affected areas were treated with both surgical resection and then radiotherapy, it is difficult to know which of those led to the adverse effects. Nonetheless, our results indicate that intraoperative radiotherapy can relieve the symptoms associated with thyroid cancer and improve the quality of life for these patients. It thus appears feasible to treat thyroid cancer patients with intraoperative radiotherapy.

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