Oncotarget

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Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma

Sha-sha Wang _, Xiao Cen, Xin-hua Liang and Ya-ling Tang

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Oncotarget. 2017; 8:10650-10661. https://doi.org/10.18632/oncotarget.12890

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Abstract

Sha-sha Wang1,2, Xiao Cen1,2, Xin-hua Liang1,2 and Ya-ling Tang1,3

1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China

2 Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China

3 Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China

Correspondence to:

Xin-hua Liang, email:

Ya-ling Tang, email:

Keywords: macrophage migration inhibitory factor; head and neck squamous cell carcinoma; tumorigenesis; metastasis; biomarker

Received: September 20, 2016 Accepted: October 19, 2016 Published: October 25, 2016

Abstract

Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.


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