Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
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Sha-sha Wang1,2, Xiao Cen1,2, Xin-hua Liang1,2 and Ya-ling Tang1,3
1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China
2 Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China
3 Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People’s Republic of China
Xin-hua Liang, email:
Ya-ling Tang, email:
Keywords: macrophage migration inhibitory factor; head and neck squamous cell carcinoma; tumorigenesis; metastasis; biomarker
Received: September 20, 2016 Accepted: October 19, 2016 Published: October 25, 2016
Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.
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