The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review

Huy Gia Vuong, Ahmed M.A. Altibi, Amr Hesham Abdelhamid, Phuong Uyen Duong Ngoc, Vo Duy Quan, Mohamed Yousef Tantawi, Mohamed Elfil, Tran Le Huy Vu, Ahmed Elgebaly, Naoki Oishi, Tadao Nakazawa, Kenji Hirayama, Ryohei Katoh, Nguyen Tien Huy and Tetsuo Kondo _

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Oncotarget. 2017; 8:10637-10649. https://doi.org/10.18632/oncotarget.12885

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Huy Gia Vuong1,2, Ahmed M.A. Altibi3, Amr Hesham Abdelhamid4, Phuong Uyen Duong Ngoc5, Vo Duy Quan6, Mohamed Yousef Tantawi7, Mohamed Elfil8, Tran Le Huy Vu9, Ahmed Elgebaly10, Naoki Oishi1, Tadao Nakazawa1, Kenji Hirayama11, Ryohei Katoh1, Nguyen Tien Huy12 and Tetsuo Kondo1

1 Department of Pathology, University of Yamanashi, Yamanashi, Japan

2 Department of Pathology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

3 Faculty of Medicine, University of Jordan, Amman, Jordan

4 Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

5 Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

6 University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

7 Faculty of Medicine, Zagazig University, Zagazig, Egypt

8 Faculty of Medicine, Alexandria University, Alexandria, Egypt

9 University of California, Los Angeles, CA, USA

10 Faculty of Medicine, Al-Azhar University, Cairo, Egypt

11 Department of Immunogenetics, Institute of Tropical Medicine, Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan

12 Department of Clinical Product Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

Correspondence to:

Tetsuo Kondo, email:

Nguyen Tien Huy, email:

Keywords: BRAF, RAS, RET/PTC, papillary, thyroid carcinoma

Received: August 02, 2016 Accepted: October 14, 2016 Published: October 25, 2016


Background: The genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time.

Methods: A literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs. Two teams of reviewers independently screened titles and abstracts of all articles. Full texts of potential articles were read and extracted data were listed and stratified into an excel file according to country, city, institution, and surgical time period. Student t test and Pearson Chi-square were used to analyze the trends of demographic and clinicopathological features of PTC patients and the prevalence of each genetic alteration in individual institutions.

Results: From 3139 articles, we included 16 articles for final analysis. Our results showed an increasing trend of BRAF and a decreasing trend of RET/PTC prevalence over time in PTCs and classical PTCs, accompanied by an older age of PTC patients, an increase in proportion of PTMC and less aggressive behaviours of tumours.

Conclusions: The demographic and clinicopathological characteristics and molecular profile of PTCs have been changing over the past few decades. These modifications suggest changes in etiologies and risk factors of thyroid cancer that influence the tumorigenesis of PTCs.

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