Twist1 promotes radioresistance in nasopharyngeal carcinoma
Metrics: PDF 1820 views | HTML 1756 views | ?
Linli Zhang1, Beibei Su1, Wei Sun1, Wenwen Li1, Min Luo1, Dongbo Liu1, Qi Mei1, Guoxian Long1, Guangyuan Hu1, Guoqing Hu1
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P.R. China
Guangyuan Hu, email: [email protected]
Guoqing Hu, email: [email protected]
Keywords: Twist1, radioresistance, nasopharyngeal carcinoma, DNA damage repair, apoptosis
Received: December 09, 2015 Accepted: September 12, 2016 Published: October 25, 2016
With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined. In this study, we found that Twist1, participating in a variety of cell biological process, was associated with the malignancy of NPC and could induce NPC radioresistance in vitro and in vivo. Mechanically, Twist1 could promote the accumulation of DNA damage repair and inhibit the apoptosis of NPC cells. Therefore, our study not only elucidates the significant role of Twist1 in radioresistance of NPC, but also highlights Twist1 as a potential therapeutic target for NPC.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.