Research Papers:

Twist1 promotes radioresistance in nasopharyngeal carcinoma

Linli Zhang, Beibei Su, Wei Sun, Wenwen Li, Min Luo, Dongbo Liu, Qi Mei, Guoxian Long, Guangyuan Hu _ and Guoqing Hu

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Oncotarget. 2016; 7:81332-81340. https://doi.org/10.18632/oncotarget.12875

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Linli Zhang1, Beibei Su1, Wei Sun1, Wenwen Li1, Min Luo1, Dongbo Liu1, Qi Mei1, Guoxian Long1, Guangyuan Hu1, Guoqing Hu1

1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P.R. China

Correspondence to:

Guangyuan Hu, email: [email protected]

Guoqing Hu, email: [email protected]

Keywords: Twist1, radioresistance, nasopharyngeal carcinoma, DNA damage repair, apoptosis

Received: December 09, 2015    Accepted: September 12, 2016    Published: October 25, 2016


With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined. In this study, we found that Twist1, participating in a variety of cell biological process, was associated with the malignancy of NPC and could induce NPC radioresistance in vitro and in vivo. Mechanically, Twist1 could promote the accumulation of DNA damage repair and inhibit the apoptosis of NPC cells. Therefore, our study not only elucidates the significant role of Twist1 in radioresistance of NPC, but also highlights Twist1 as a potential therapeutic target for NPC.

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