Oncotarget

Research Papers:

Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application

Fengliu Deng, Mingwen Ouyang, Xiaofei Wang, Xueqing Yao, Yeming Chen, Tao Tao, Xuegang Sun, Lijun Xu, Jing Tang and Liang Zhao _

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Oncotarget. 2016; 7:77087-77095. https://doi.org/10.18632/oncotarget.12800

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Abstract

Fengliu Deng1,2,*, Mingwen Ouyang3,*, Xiaofei Wang4, Xueqing Yao5, Yeming Chen6, Tao Tao4, Xuegang Sun7, Lijun Xu1,2, Jing Tang4, Liang Zhao1,2

1Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

2Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

3Department of anesthesia, Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China

4Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

5Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong, China

6Department of Anesthesia, Huarui Hospital, Southern Medical University, Guangzhou, Guangdong, China

7The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China

*These authors contributed equally to this work

Correspondence to:

Liang Zhao, email: [email protected]

Jing Tang, email: [email protected]

Keywords: epithelial-mesenchymal transition, colorectal cancer, dexmedetomidine, propofol, etomidate

Received: May 27, 2016     Accepted: October 17, 2016     Published: October 21, 2016

ABSTRACT

Anesthetics are unavoidable to colorectal cancer (CRC) patients who underwent surgical treatment. Thus, the molecular mechanisms underlying the role of the intravenous anesthetics in CRC metastasis are still unclear. In this study, the effects of intravenous anesthetics, such as propofol, etomidate and dexmedetomidine, on cell migration were determined. The migration of CRC cells was inhibited by propofol in vitro, but not in vivo. Etomidate, however, promoted the migration of CRC cells both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) mediated the promotive effect of propofol and etomidate on the migration of CRC cells through PI3K/AKT signaling pathway. Dexmedetomidine alone or in combination with propofol or etomidate had minor effect on the migration of CRC cells. These findings indicate that propofol inhibites CRC cell migration in vitro. Etomidate playes a role for prompting CRC metastasis progression by activating (PI3K)/AKT signaling and inducing EMT. It provides an important hint for the clinical application of these anesthetics.


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