Application of intensity-modulated radiotherapy in unresectable poorly differentiated thyroid carcinoma

Fen Xue; Duanshu Li; Chaosu Hu; Zhuoying Wang; Xiayun He; Yi Wu

doi:10.18632/oncotarget.12785

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Clinical Research Papers:

Application of intensity-modulated radiotherapy in unresectable poorly differentiated thyroid carcinoma

Fen Xue, Duanshu Li, Chaosu Hu, Zhuoying Wang, Xiayun He _ and Yi Wu

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Oncotarget. 2017; 8:15934-15942. https://doi.org/10.18632/oncotarget.12785

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Abstract

Fen Xue1, Duanshu Li2, Chaosu Hu1, Zhuoying Wang2, Xiayun He1 and Yi Wu2

1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

2 Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

Correspondence to:

Xiayun He, email:

Yi Wu, email:

Keywords: unresectable poorly differentiated thyroid carcinoma; intensity modulated radiotherapy; chemotherapy; locoregional control; distant metastases

Received: July 10, 2016 Accepted: October 13, 2016 Published: October 20, 2016

Abstract

Poorly differentiated thyroid carcinoma (PDTC) is a rare and aggressive malignancy with high rates of invasion and distant metastasis. This study was to explore the ability of intensity-modulated radiotherapy (IMRT) combined with chemotherapy to manage unresectable PDTC. Between February 2011 and April 2012, 5 patients with unresectable PDTC were treated by IMRT at our institution and were included in this analysis. The median radiotherapy dose to the gross tumor volume (GTV) was 66 Gy/33 fractions/6.4 weeks. All patients received chemotherapy, and one patient with tumor compression symptoms had a tracheotomy before treatment. The mean survival time of the 5 patients was 41.6 months. The direct causes of death were distant metastases (40%) and progression of the locoregional disease (20%). In conclusion, IMRT combined with chemotherapy for unresectable PDTC might be beneficial to improve locoregional control. Further new therapies are needed to control metastases.

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Clinical Research Papers:

Application of intensity-modulated radiotherapy in unresectable poorly differentiated thyroid carcinoma

Abstract