Oncotarget

Research Papers:

Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma

Jingjing Yu, Yuling Huang, Lijuan Liu, Jing Wang, Jiye Yin, Lihua Huang, Shaojun Chen, Jingao Li, Hong Yuan, Guoping Yang, Wenyu Liu, Hai Wang, Qi Pei and Chengxian Guo _

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Oncotarget. 2016; 7:82528-82537. https://doi.org/10.18632/oncotarget.12754

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Abstract

Jingjing Yu1, Yuling Huang2, Lijuan Liu3, Jing Wang2, Jiye Yin4, Lihua Huang5, Shaojun Chen6, Jingao Li2, Hong Yuan1, Guoping Yang1, Wenyu Liu7, Hai Wang8, Qi Pei1, Chengxian Guo1

1Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China

2Department of Radiation Oncology, Jiangxi Province Tumor Hospital, Nanchang, Jiangxi 330029, China

3Department of Pharmacy, Jiangxi Cancer Hospital, Nanchang 330029, China

4Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

5Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China

6Department of Oncology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, Guangxi 545005, China

7College of Pharmacy, Central South University, Changsha, Hunan 410008, China

8Xiangya Medical College, Central South University, Changsha, Hunan 410008, China

Correspondence to:

Chengxian Guo, email: gchxyy@163.com

Keywords: nasopharyngeal carcinoma (NPC), Wnt/β-catenin pathway, single nucleotide polymorphism (SNP), curative efficacy, toxic reaction

Received: May 22, 2016     Accepted: October 14, 2016     Published: October 19, 2016

ABSTRACT

Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established whether SNPs of Wnt/β-catenin pathway are associated with nasopharyngeal tumorigenesis and the efficacy of RT in NPC patients. Therefore, in this study, we aimed to investigate the nine potentially functional SNPs of four genes in the Wnt/β-catenin pathway and genotyped these in 188 NPC patients treated with RT. To achieve this goal, associations between these SNPs and the RT’s curative efficacy, as well as acute radiation-induced toxic reaction were determined by multifactorial logistic regression. We observed that catenin beta 1 gene (CTNNB1) rs1880481 and rs3864004, and glycogen synthase kinase 3 beta gene (GSK3β) rs3755557 polymorphisms were significantly associated with poorer efficacy of RT in NPC patients. Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3–4 radiation-induced dermatitis and oral mucositis, respectively. In conclusion, this study suggests that gene polymorphisms of Wnt/β-catenin may be novel prognostic factors for NPC patients treated with RT.


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