Implications of immune dysfunction on endometriosis associated infertility

Jessica E. Miller, Soo Hyun Ahn, Stephany P. Monsanto, Kasra Khalaj, Madhuri Koti and Chandrakant Tayade _

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Oncotarget. 2017; 8:7138-7147. https://doi.org/10.18632/oncotarget.12577

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Jessica E. Miller1, Soo Hyun Ahn1, Stephany P. Monsanto1, Kasra Khalaj1, Madhuri Koti1 and Chandrakant Tayade1

1 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

Correspondence to:

Chandrakant Tayade, email:

Keywords: inflammation, cytokines, oxidative stress, infertility, endometriosis

Received: September 09, 2016 Accepted: October 05, 2016 Published: October 11, 2016


Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility. We discuss the implication of the peritoneal inflammatory microenvironment on various factors that contribute to infertility such as hormonal imbalance, oxidative stress and how these could further lead to poor oocyte, sperm and embryo quality, impaired receptivity of the endometrium and implantation failure.

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