Oncotarget

Clinical Research Papers:

Prognostic value of a novel risk classification of microvascular invasion in patients with hepatocellular carcinoma after resection

Hui Zhao, Chuang Chen, Xu Fu, Xiaopeng Yan, Wenjun Jia, Liang Mao, Huihan Jin and Yudong Qiu _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:5474-5486. https://doi.org/10.18632/oncotarget.12547

Metrics: PDF 1727 views  |   HTML 1563 views  |   ?  


Abstract

Hui Zhao1,2,*, Chuang Chen1,3,*, Xu Fu4,*, Xiaopeng Yan4, Wenjun Jia4, Liang Mao4, Huihan Jin2 and Yudong Qiu1,4

1 Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China

2 Department of Hepatopancreatobiliary Surgery, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu, China

3 Department of Hepatopancreatobiliary Surgery, Huai’an Hospital Affiliated to Xuzhou Medical University, Second People’s Hospital of Huai’an City, Huai’an, Jiangsu, China

4 Department of Hepatopancreatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

* These authors have contributed equally to this work

Correspondence to:

Yudong Qiu, email:

Huihan Jin, email:

Keywords: hepatocellular carcinoma; microvascular invasion; risk classification; prognosis

Received: July 16, 2016 Accepted: September 21, 2016 Published: October 09, 2016

Abstract

Objectives: The present research aimed to evaluate the prognostic value of a novel risk classification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) after resection.

Methods: A total of 295 consecutive HCC patients underwent hepatectomy were included in our study. We evaluated the degree of MVI according to the following three features: the number of invaded microvessels (≤5 vs >5), the number of invading carcinoma cells (≤ 50 vs >50), the distance of invasion from tumor edge (≤1 cm vs >1 cm).

Results: All patients were divided into three groups according to the three risk factors of MVI: non-MVI group (n=180), low-MVI group (n=60) and high-MVI group (n=55). The overall survival (OS) and recurrence-free survival (RFS) rates of high-MVI group were significantly poorer than those of low-MVI and non-MVI groups (P<0.001 and P=0.001; P<0.001 and P=0.003). Multivariate analysis showed high-MVI, type of resection, ICG-R15 and tumor size were risk factors for OS after hepatectomy. High-MVI, type of resection and tumor size were risk factors for RFS. In subgroup analyses, the OS and RFS rates of low-MVI and non-MVI groups were better than high-MVI group regardless of tumor size. In high-MVI group, anatomical liver resection (n=28) showed better OS and RFS rates compared with non-anatomical liver resection (n=29) (P=0.012 and P=0.002).

Conclusions: The novel risk classification of MVI based on histopathological features is valuable for predicting prognosis of HCC patients after hepatectomy.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 12547