Clinical Research Papers:

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

Xiao Du, Si-qin Zhang, Hong-xu Zhou, Xue Li, Xiao-juan Zhang, Zong-guang Zhou and Zhong Cheng _

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Oncotarget. 2016; 7:76308-76315. https://doi.org/10.18632/oncotarget.12536

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Xiao Du1,*, Si-qin Zhang2,*, Hong-xu Zhou1, Xue Li1, Xiao-juan Zhang2, Zong-guang Zhou1 and Zhong Cheng1

1 Department of Gastrointestinal Surgery, Laboratory of Bariatric and Metabolic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China

2 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, P.R. China

* These authors have contributed equally to this study

Correspondence to:

Zhong Cheng, email:

Keywords: bariatric surgery; Roux-en-Y gastric bypass; sleeve gastrectomy; morbid obesity; weight loss

Received: August 17, 2016 Accepted: October 05, 2016 Published: October 08, 2016


Objectives: This 1:1 matched cohort study with 3-year follow-up aimed to compare the safety and efficacy of LSG with LRYGB for morbid obesity patients.

Methods: From 2009 to 2013, patients undergoing LRYGB (n = 63) were matched with LSG (n = 63) by gender, age, and body mass index (BMI). Major complications, BMI, percentage of excess weight loss (%EWL), and obesity-related comorbidities after 6, 12, 24, and 36 months were compared.

Results: Hospital stay and major complication rates were comparable, but operative time in LSG was significantly shorter (83.2 ± 23.7 vs. 108.3 ± 21.3 min). No significant differences in mean %EWL and BMI were observed at 6, 12, 24 months. At 3-year follow-up, mean %EWL in the LRYGB group was significantly higher than in the LSG group (76.5 ± 9.2% vs. 65.7 ± 10.3%) and, consequently, mean BMI was significantly lower in LRYGB (28.2 ± 1.5 vs. 30.9 ± 2.4 kg/m2). No significant differences in remission of comorbidities were observed at 1- or 3-year follow-up.

Conclusions: Both LRYGB and LSG were safe and effective bariatric procedures in this Chinese population, but LRYGB seemed to be superior to LSG in terms of mid-term weight loss.

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