Clinical Research Papers:
Fertility-sparing surgery for patients with low-grade endometrial stromal sarcoma
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Weimin Xie1, Dongyan Cao1, Jiaxin Yang1, Xuan Jiang1, Keng Shen1, Lingya Pan1, Huifang Huang1, Jinghe Lang1, Yan You2 and Jie Chen2
1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jiaxin Yang, email:
Keywords: fertility-sparing surgery, low-grade, endometrial stromal sarcoma , recurrence, pregnancy
Received: August 08, 2016 Accepted: September 29, 2016 Published: October 06, 2016
Purpose: To assess the clinical outcomes and fertility of young women with stage I low-grade endometrial stromal sarcoma (ESS) treated with fertility-sparing surgery.
Results: Seventeen patients with stage I low-grade ESS (stage IA, n = 6; stage IB, n = 11) were entered into this study. Adjuvant hormone therapy was administered to 15 (88.2%) patients. At a median follow-up of 39 months (range, 4–106 months), 10 (58.8%) patients developed recurrence. All 10 patients had stage IB disease; among them, the first recurrence limited to the uterus was observed in 6 patients. All 17 patients were alive and disease-free at the time of last contact. After treatment, five of eight (62.5%) patients who attempted pregnancy conceived. No offspring had congenital anomalies.
Methods: Patients with stage I low-grade ESS who underwent fertility-sparing surgery between April 2001 and November 2015 were retrospectively reviewed.
Conclusions: Fertility-sparing surgery may be considered for young patients with stage IA low-grade ESS who wish to preserve their fertility.
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