Protective effects of oxymatrine against arsenic trioxide-induced liver injury

Li Li; Qinghai Liu; Long Fan; Wei Xiao; Lei Zhao; Yu Wang; Weiguang Ye; Fei Lan; Bin Jia; Hua Feng; Changman Zhou; Xiuqin Yue; Guogang Xing; Tianlong Wang

doi:10.18632/oncotarget.12478

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Research Papers:

Protective effects of oxymatrine against arsenic trioxide-induced liver injury

Li Li, Qinghai Liu, Long Fan, Wei Xiao, Lei Zhao, Yu Wang, Weiguang Ye, Fei Lan, Bin Jia, Hua Feng, Changman Zhou, Xiuqin Yue, Guogang Xing _ and Tianlong Wang

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Oncotarget. 2017; 8:12792-12799. https://doi.org/10.18632/oncotarget.12478

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Abstract

Li Li1, Qinghai Liu1, Long Fan1, Wei Xiao1, Lei Zhao1, Yu Wang1, Weiguang Ye1, Fei Lan1, Bin Jia1, Hua Feng1, Changman Zhou2, Xiuqin Yue3, Guogang Xing4, Tianlong Wang1

1Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China

2Department of Anatomy & Histology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

3Department of Anesthesiology, the First Affiliated Hospital of Xinxiang Medical University, Henan, China

4Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China

Correspondence to:

Guogang Xing, email: [email protected]

Tianlong Wang, email: [email protected]

Keywords: oxymatrine, arsenic trioxide, liver, HO-1, Nrf-2

Received: July 25, 2016 Accepted: September 06, 2016 Published: October 5, 2016

ABSTRACT

Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As₂O₃)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As₂O₃-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As₂O₃ intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As₂O₃ treatment. The results showed that oxymatrine inhibited As₂O₃-induced hepatic pathological damage, liver ROS level and MDA level in a dose-dependent manner. As₂O₃ decreased the antioxidant enzymes SOD, GPX, and CAT activity and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As₂O₃-induced oxidative damage by activating Nrf2/HO-1 signaling pathway.

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Research Papers:

Protective effects of oxymatrine against arsenic trioxide-induced liver injury

Abstract