Research Papers:

Advanced lung adenocarcinomas with ROS1-rearrangement frequently show hepatoid cell

Jing Zhao _, Jing Zheng, Mei Kong, Jianya Zhou, Wei Ding and Jianying Zhou

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Oncotarget. 2016; 7:74162-74170. https://doi.org/10.18632/oncotarget.12364

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Jing Zhao1,*, Jing Zheng2,*, Mei Kong1, Jianya Zhou2, Wei Ding1, Jianying Zhou2

1Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

2Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

*These authors have contributed equally to this work

Correspondence to:

Jing Zhao, email: [email protected]

Keywords: NSCLCs, ROS1 rearrangement, clinicopathological features, biopsy

Received: May 30, 2016    Accepted: September 16, 2016    Published: September 30, 2016


Defining distinctive histologic characteristics of ROS1-rearranged non-small-cell lung carcinomas (NSCLCs) may help identify cases that merit molecular testing. However, the majority of previous reports have focused on surgical specimens but only limited studies assessed histomorphology of advanced NSCLCs. In order to identify the clinical and histological characteristics of ROS1-rearranged advanced NSCLCs, we examined five hundred sixteen Chinese patients with advanced NSCLCs using ROS1 fluorescence in situ hybridization and real-time polymerase chain reaction and then analyzed for clinical and pathological features. We performed univariate and multivariate analyses to identify predictive factors associated with ROS1 rearrangement. 19 tumors were identified with ROS1 rearrangement (3.7% of adenocarcinomas). 16 ROS1+ and 122 ROS1- samples with available medical records and enough tumor cells were included for histological analysis. Compared with ROS1-negative advanced NSCLCs,ROS1-rearranged advanced NSCLCs were associated with a younger age at presentation. ROS1 rearrangements were not significantly associated with sex, smoking history, drinking history and metastatic sites. The most common histological pattern was solid growth (12/16), followed by acinar (4/16) growth. 66.7% cases with solid growth pattern showed hepatoid cytology (8/12) and 75% cases with acinar growth pattern showed a cribriform structure (3/4). 18.8% cases were found to have abundant extracellular mucus or signet-ring cells (3/16). Only one case with solid growth pattern showed psammomatous calcifications. In conclusion, age, hepatoid cytology and cribriform structure are the independent predictors for ROS1-rearranged advanced NSCLCs, recognizing these may be helpful in finding candidates for genomic alterations, especially when available tissue samples are limited.

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