Oncotarget

Research Papers:

Clinicopathological characteristics and long-term prognosis of screening detected non-palpable breast cancer by ultrasound in hospital-based Chinese population (2001-2014)

Bo Pan, Ru Yao, Qing-Li Zhu, Chang-Jun Wang, Shan-Shan You, Jing Zhang, Qian-Qian Xu, Feng Cai, Jie Shi, Yi-Dong Zhou, Feng Mao, Yan Lin, Jing-Hong Guan, Song-Jie Shen, Zhi-Yong Liang, Yu-Xin Jiang and Qiang Sun _

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Oncotarget. 2016; 7:76840-76851. https://doi.org/10.18632/oncotarget.12319

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Abstract

Bo Pan1,*, Ru Yao1,*, Qing-Li Zhu2,*, Chang-Jun Wang1, Shan-Shan You2, Jing Zhang2, Qian-Qian Xu1, Feng Cai3, Jie Shi4, Yi-Dong Zhou1, Feng Mao1, Yan Lin1, Jing-Hong Guan1, Song-Jie Shen1, Zhi-Yong Liang4, Yu-Xin Jiang2, Qiang Sun1

1Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China (100730)

2Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China (100730)

3Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China (100730)

4Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China (100730)

*These authors have contributed equally to this work

Correspondence to:

Qiang Sun, email: sunqiang_pumc@163.com

Keywords: non-palpable breast cancer, screening, ultrasound, prognosis

Received: August 01, 2016     Accepted: September 12, 2016     Published: September 28, 2016

ABSTRACT

Purpose: The mainstay modality of breast cancer screening in China is the hospital-based opportunistic screening among asymptomatic self-referred women. There is little data about the ultrasound (US) detected non-palpable breast cancer (NPBC) in Chinese population.

Methods: We analyzed 699 consecutive NPBC from 1.8-2.3 million asymptomatic women from 2001 to 2014, including 572 US-detected NPBC from 3,786 US-positive women and 127 mammography (MG) detected NPBC from 788 MG-positive women. The clinicopathological features, disease-free survival (DFS) and overall survival (OS) were compared between the US- and MG-detected NPBC. Prognostic factors of NPBC were identified.

Results: Compared to MG, US could detect more invasive NPBC (83.6% vs 54.3%, p<0.001), lymph node positive NPBC (19.1% vs 10.2%, p=0.018), lower grade (24.8% vs 16.5%, p<0.001), multifocal (19.2% vs 6.3%, p<0.001), PR positive (71.4% vs 66.9%, p=0.041), Her2 negative (74.3% vs 54.3%, p<0.001), Ki67 high (defined as >14%, 46.3% vs 37.0%, p=0.031) cancers and more NPBC who received chemotherapy (40.7% vs 21.3%, p<0.001). There was no significant difference in 10-year DFS and OS between US-detected vs MG-detected NPBC, DCIS and invasive NPBC. For all NPBC and the US-detected NPBC, the common DFS-predictors included pT, pN, p53 and bilateral cancers.

Conclusion: US could detect more invasive, node-positive, multifocal NPBC in hospital-based asymptomatic Chinese female, who could achieve comparable 10-year DFS and OS as MG-detected NPBC. US would not delay early detection of NPBC with improved cost-effectiveness, thus could serve as the feasible initial imaging modality in hospital-based opportunistic screening among Chinese women.


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